We cannot avoid artificial intelligence, which has the potential to reshape the healthcare landscape – from improving clinical workflows and optimizing operational processes to redefining patient care delivery. This opening keynote panel will side-step the hype and focus on how AI is actually being deployed beyond pilot stage, encompassing the people (both staff and patients), the process to leverage the technology, and the outcomes delivered in implementation. Picking up on the critical challenges of AI adoption, including data security, governance and ethics, financial sustainability and ROI, this will set the stage for innovation-driven discussions throughout HPN San Diego.